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Advise patients to immediately report any signs or symptoms suggesting allergic reaction or angioedema, and to take no more of the drug until they have consulted prescribing physicians

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It is worth noting that febuxostat inhibits ABCG2 more strongly than the two known ABCG2 inhibitors (Ko143 and elacrida), which means that febuxostat has not only advantages over these two inhibitors but also stronger in safety and ability than other ABCG2 inhibitor (Allen et al., 2002)

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